DHA Metabolism: Targeting the Brain and Lipoxygenation (PDF ...
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17 maj 2016 - This paper reviews how it could accumulate through specific uptake of DHA-
Abstract
Docosahexaenoic
acid (DHA), the end-product of the metabolism of omega-3 family fatty
acids, is the main polyunsaturated fatty acid of the brain, but its
accumulation is incompletely understood. This paper reviews how it could
accumulate through specific uptake of DHA-containing
lysophosphatidylcholine (LysoPC-DHA).


DHA migrates very easily from the
sn-2 position of LysoPC, which could be considered as the physiological
form of polyunsaturated LysoPC, to the sn-1 position, which is much more
stable.
An approach preventing migration by acetylating the sn-1
position, while retaining the main physico-chemical properties of the
carrier, is described.
Also, the double lipoxygenation and
bond-isomerization of DHA into
10(S),17(S)-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by
soybean lipoxygenase is described. As in other E,Z,E conjugated trienes,
PDX is shown to inhibit human blood platelet aggregation at
submicromolar concentrations.
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