DHA aineenvaihdunnasta artikkeli (2016)

DHA Metabolism: Targeting the Brain and Lipoxygenation (PDF ...

https://www.researchgate.net/.../43346505_DHA_Metabolism_T... - Översätt den här sidan

17 maj 2016 - This paper reviews how it could accumulate through specific uptake of DHA-containing lysophosphatidylcholine (LysoPC-DHA). DHA migrates

Abstract

Docosahexaenoic acid (DHA), the end-product of the metabolism of omega-3 family fatty acids, is the main polyunsaturated fatty acid of the brain, but its accumulation is incompletely understood. This paper reviews how it could accumulate through specific uptake of DHA-containing lysophosphatidylcholine (LysoPC-DHA).

 

 DHA migrates very easily from the sn-2 position of LysoPC, which could be considered as the physiological form of polyunsaturated LysoPC, to the sn-1 position, which is much more stable.

 An approach preventing migration by acetylating the sn-1 position, while retaining the main physico-chemical properties of the carrier, is described. 

Also, the double lipoxygenation and bond-isomerization of DHA into 10(S),17(S)-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by soybean lipoxygenase is described. As in other E,Z,E conjugated trienes, PDX is shown to inhibit human blood platelet aggregation at submicromolar concentrations.