S1P kuuluu niihin lysofasfolipideihin (LPL) joita sfingomyeliinin kataboliasta muodostuu. Alla on mainittu myös lysofosfatidaatti LPA. Sillöäkin on omat reseptiorit.
From Wikipedia, the free encyclopedia
LigandsThe ligands for LPL-R group are the lysophospholipid extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P).
Origin of nameThe term lysophospholipid (LPL) refers to any phospholipid that is missing one of its two O-acyl chains. Thus, LPLs have a free alcohol in either the sn-1 or the sn-2 position. The prefix 'lyso-' comes from the fact that lysophospholipids were originally found to be hemolytic, however it is now used to refer generally to phospholipids missing an acyl chain. LPLs are usually the result of phospholipase A-type enzymatic activity on regular phospholipids such as phosphatidylcholine or phosphatidic acid, although they can also be generated by the acylation of glycerophospholipids or the phosphorylation of monoacylglycerols. Some LPLs serve important signaling functions such as lysophosphatidic acid.
FunctionLPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventing apoptosis and increasing cell proliferation.
Group membersThe following is a list of the eleven known human LPL receptors:
|Gene Symbol||IUPHAR Symbol||Gene / Protein Name||Agonist Ligand||Synonyms|
|LPAR1||lysophosphatidic acid receptor 1||LPA||EDG2|
|LPAR2||lysophosphatidic acid receptor 2||"||EDG4|
|LPAR3||lysophosphatidic acid receptor 3||"||EDG7|
|LPAR4||LPA4||lysophosphatidic acid receptor 4||"||GPR23|
|LPAR5||LPA5||lysophosphatidic acid receptor 5||"||GPR92|
|LPAR6||LPA6||lysophosphatidic acid receptor 6||"||P2RY5|
|S1PR1||sphingosine-1-phosphate receptor 1||S1P||EDG1|
|S1PR2||sphingosine-1-phosphate receptor 2||"||EDG5|
|S1PR3||sphingosine-1-phosphate receptor 3||"||EDG3|
|S1PR4||sphingosine-1-phosphate receptor 4||"||EDG6|
|S1PR5||sphingosine-1-phosphate receptor 5||"||EDG8|