Samassa geenissä kuin TRIM47 on myös ACOX

Olen katsomasas kromosomin 17 TRIM-proteiineja.
kromosomilocus 17q25.1,  missä sijaitsee  TRIM47 onkin  sellainen että  siihen sijoittuu tietty joukko   kiinnostusta herättävää geeniä.
Yksi näistä koskee rasvahappoaineenvaihduntaa ja on peroksisomaalinen:  ACOX1, PALMCOX on  betaoksidaatiossa  tärkeä.
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACOX1
Otan talteen sen nimet ja vähän tietoa siitä:

Entrez Gene Summary for ACOX1 Gene

• The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  

GeneCards Summary for ACOX1 Gene

ACOX1 (Acyl-CoA Oxidase 1) is a Protein Coding gene. Diseases associated with ACOX1 include Peroxisomal Acyl-Coa Oxidase Deficiency and Adrenoleukodystrophy. Among its related pathways are Estrogen Receptor Pathway and Peroxisomal lipid metabolism. Gene Ontology (GO) annotations related to this gene include receptor binding and protein N-terminus binding. An important paralog of this gene is ACOX2.

UniProtKB/Swiss-Prot for ACOX1 Gene

• ACOX1_HUMAN,Q15067

• Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
  

Aliases for ACOX1 Gene

• SCOX ^{3 4}
• AOX ^{3 4}
• Peroxisomal Acyl-Coenzyme A Oxidase 1 ³
• Peroxisomal Fatty Acyl-CoA Oxidase ³
• Acyl-CoA Oxidase, Straight-Chain ³
• PALMCOX ³

• Acyl-CoA Oxidase 1 ^{2 3 5}
• Palmitoyl-CoA Oxidase ^{2 3 4}
• Acyl-Coenzyme A Oxidase 1, Palmitoyl ^{2 3}
• Straight-Chain Acyl-CoA Oxidase ^{3 4}
• Acyl-CoA Oxidase 1, Palmitoyl ^{2 3}
• EC 1.3.3.6 ^{4 56}
• ACOX ^{3 4}

• ^{TARKISTAN missä geenissä sijaitsee ACOX2 ja mitä se tekee.  Ei ainakaan samassa geenissä, vaan kromosomissa 3p14.3.}

•  ^{http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACOX2}

• Aliases for ACOX2 Gene

  • Acyl-CoA Oxidase 2 ^{2 3 5}
  • 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA 24-Hydroxylase ^{2 3 4}
  • Trihydroxycoprostanoyl-CoA Oxidase ^{2 3 4}
  • 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA Oxidase ^{3 4}
  • Acyl-Coenzyme A Oxidase 2, Branched Chain ^{2 3}
  • Acyl-CoA Oxidase 2, Branched Chain ^{2 3}
  • Branched Chain Acyl-CoA Oxidase ^{2 3}
  • THCA-CoA Oxidase ^{3 4}
  • THCCox ^{3 4}
  • Peroxisomal Branched Chain Acyl-CoA Oxidase ³
  • Peroxisomal Acyl-Coenzyme A Oxidase 2 ³
  • EC 1.17.99.3 ⁴
  • BRCACOX ³
  • BRCOX ³
  • CBAS6 ³
  • BCOX ³