Tässä artikkelisas on tutkittu koko joukko eriälaisia lipidialkoholeja, niiden ominaisuuksia ja miten ne muuntavat solukalvoa.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175087/
Biophys J. 2011 Aug 17; 101(4): 847–855.
PMCID: PMC3175087
Alcohol's Effects on Lipid Bilayer Properties
Abstract
Alcohols
are known modulators of lipid bilayer properties. Their biological
effects have long been attributed to their bilayer-modifying effects,
but alcohols can also alter protein function through direct protein
interactions. This raises the question: Do alcohol's biological actions
result predominantly from direct protein-alcohol interactions or from
general changes in the membrane properties? The efficacy of alcohols of
various chain lengths tends to exhibit a so-called cutoff effect (i.e.,
increasing potency with increased chain length, which that eventually
levels off). The cutoff varies depending on the assay, and numerous
mechanisms have been proposed such as: limited size of the
alcohol-protein interaction site, limited alcohol solubility, and a
chain-length-dependent lipid bilayer-alcohol interaction. To address
these issues, we determined the bilayer-modifying potency of 27
aliphatic alcohols using a gramicidin-based fluorescence assay. All of
the alcohols tested (with chain lengths of 1–16 carbons) alter the
bilayer properties, as sensed by a bilayer-spanning channel. The
bilayer-modifying potency of the short-chain alcohols scales linearly
with their bilayer partitioning; the potency tapers off at higher chain
lengths, and eventually changes sign for the longest-chain alcohols,
demonstrating an alcohol cutoff effect in a system that has no
alcohol-binding pocket.
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