Alcohol abuse and alcoholism are international problems whose costs
economically, psychologically and medically have been well documented.
Alcohol is a unique drug in that the effects of excessive use can have a
deleterious effect on most if not all organs of the body.
The brain is
one of the organs most affected by excessive alcohol consumption.
Effects on the brain can be seen in cognitive function, brain structure
Over the past few years, there have been significant
advances made in understanding how alcohol affects brain
This book examines four major areas, i. e. ,
receptors and ion channels,
second messengers, and
expression, where significant advancements have been made.
The book is
divided into four sections based on the four major areas. In each
section, data are examined that cover a range of approaches from in
vitro to in vivo studies.
The section on membrane lipids includes recent
developments in how ethanol affects membrane cholesterol domains,
polyunsaturated fatty acids, the cause and consequences of
phosphatidylethanol formation, and the modulation of membrane protein
function by lipid-protein interaction.
The second section comprises
chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol
neurotoxicity and the molecular heterogeneity that may underlie
differences in alcohol sensitivity as well as chapters on GABA-gated
chloride flux, and calcium channels.
1946 syntynyt Tampereella
Ylioppilastutkinto 1964 Lempäälä
Lääketietaan kandidaatti 1966 Turun yliopisto
Lääketieteen lisensiaatti 1972 Turun Yliopisto
Dietetiikan opiskelu 1998 - 2001 Göteborgin Yliopisto