MDA pitoisuuus B12- vitamiinin puutteessa.

MALONIDIALDEHYDI suomeksi
http://www.ilo.org/dyn/icsc/showcard.display?p_lang=fi&p_card_id=1632
Malonidialdehydi
1,3-Propaanidialdehydi

Tutkittu oksidatiivisen stressin merkitsijöitä B12-vitamiinin  puutteessa:

Vitamiini B12- puute korreloi kohonneeseen malondialdehydipitoisuuteen. 

Oxidative Stress Markers in Vitamin B12 Deficiency. - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/26843105
av UK Misra - ‎2016 - ‎Citerat av 2 - ‎Relaterade artiklar
3 feb. 2016 -
In this study, we report the status of oxidative stress markers
in vitamin B12 deficiency and their relation to clinical, laboratory, and neurophysiological findings.
Fifty-one subjects with serum vitamin B12 deficiency (<211 br="" included.="" ml="" pg="" were="">Plasma glutathione (GSH), malondialdehyde (MDA) and serum ...

Mol Neurobiol. 2017 Mar;54(2):1278-1284. doi: 10.1007/s12035-016-9736-2. Epub 2016 Feb 3.
Oxidative Stress Markers in Vitamin B12 Deficiency.
Misra UK1, Kalita J2, Singh SK2, Rahi SK2.
Author information

Abstract

In this study, we report the status of oxidative stress markers in vitamin
 B12 deficiency and their relation to clinical, laboratory, and neurophysiological findings.  Fifty-one subjects with serum vitamin B12 deficiency (<211 br="" included.="" ml="" pg="" were="">Plasma glutathione (GSH),
 malondialdehyde (MDA) and 
serum total antioxidant capacity (TAC) were measured in the patients and 53 controls.
These markers were also compared between subacute combined degeneration (SACD) and non-SACD vitamin B12 deficiency patients groups as well as with normal controls.

 In the patients, GSH, MDA and TAC were correlated with demographic,
 clinical, hematological, biochemical, nerve conduction study (NCS), visual evoked potential (VEP) and somatosensory-evoked potential (SEP) findings.
In the study group, 20 (39.2 %) patients had  SACD manifesting with myeloneuropathy, cognitive or behavioral abnormalities, and 31(60.8 %)
patients had non-SACD neurological manifestations.
The GSH (2.46 ± 0.32 vs. 2.70 ± 0.36 mg/dl; P = 0.002) and
TAC (2.13 ± 0.38 vs. 2.33 ± 0.24 nmol Trolox eq/l, P = 0.005) levels were lower,
and MDA levels (4.01 ± 0.69 vs. 3.00 ± 0.45 nmol/ml, P < 0.001) were higher
in B12 deficiency group compared with controls.
 Similar trend was found in SACD and non-SACD vitamin B12 deficiency groups.
GSH levels correlated with abnormal VEP (r = 0.54; P < 0.01),
TAC with female gender (r = 0.43; P = 0.002) and
joint position impairment (r = -0.34; P = 0.01),
and MDA with LDH (r = 0.41; P = 0.01).
 Vitamin B12 deficiency was associated with reduction in GSH and TAC and
increase in MDA levels which were more marked in SACD compared to non-SACD group.
KEYWORDS:

Glutathione; Malondialdehyde; Nerve conduction study; Oxidative stress; Subacute combined degeneration;
Total antioxidant capacity; Visual evoked potential; Vitamin B12

PMID:
    26843105
DOI:
    10.1007/s12035-016-9736-2