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torsdag 7 december 2017

Funktioilta tuntemattomia eoxamideja olemassa

Eoxamides

The same pathways that metabolize arachidonic acid to eoxines have been shown to metabolize anandamide, N-arachidonoylethanolamine (i.e. arachidonic acid containing ethanolamine esterified to its carboxy residue) into a set of eoxamides that are identical to their eoxin counterparts except that they possess an ethanolamine ester. These metabolites have been named EXA4 ethanol amide, EXC4 ethanol amide, EXD4 ethanol amide, and EXE4 ethanol amide. These products were formed by the L1236 Reed Sternberg cell line presented with anandamide; human platelets presented with eoxamideA4 produced EXC4 ethanol amide, EXD4 ethanol amide, and EXE4 ethanol amide. The activity and function of these ethanol amide metabolites has not been reported.[4]

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