Eoxamides
The same pathways that metabolize arachidonic acid to eoxines have been shown to metabolize
anandamide,
N-arachidonoylethanolamine
(i.e. arachidonic acid containing ethanolamine esterified to its
carboxy residue) into a set of eoxamides that are identical to their
eoxin counterparts except that they possess an ethanolamine ester. These
metabolites have been named EXA
4 ethanol amide, EXC
4 ethanol amide, EXD
4 ethanol amide, and EXE
4
ethanol amide. These products were formed by the L1236 Reed Sternberg
cell line presented with anandamide; human platelets presented with
eoxamideA
4 produced EXC
4 ethanol amide, EXD
4 ethanol amide, and EXE
4 ethanol amide. The activity and function of these ethanol amide metabolites has not been reported.
[4]
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