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onsdag 6 juni 2018

Kerebronihappo , 2-hydroxytetrakosaanihappo

2-Hydroxytetracosanoic acid.png 
https://pubchem.ncbi.nlm.nih.gov/compound/2-Hydroxytetracosanoic_acid#section=Top

C24H48O

Tämä rasvahappo vaatii oksidaatiossaan alfa-oksidaation, mistä voi tulla jollekin yksilöille ongelmaa alfa-oksidaation  heikkouden takia.  se vaatii peroksisomaalisen oksidaation.
https://www.ncbi.nlm.nih.gov/pubmed/11104019 
Tällä  rasvahappomuodolla näyttää oelvan useampiakin  merkityksiä tautipuolella. 

Tällä hapolla on paljon synonyymisiä nimiä:
  1. 2-Hydroxytetracosanoic acid
  2. Cerebronic acid
  3. 544-57-0
  4. Phrenosic acid
  5. Phrenosinic acid
  6. DL-Cerebronic acid
  7. 2-hydroxy-tetracosanoic acid
  8. Cerebronsaeure
  9. acide cerebronique
  10. a-hydroxylignoceric acid
    1. 2-hydroxylignoceric acid
    2. AC1L2SRS
    3. 2-Hydroxy-tetracosansaeure
    4. 2-hydroxytetraicosanoic acid
    5. AC1Q5ST6
    6. 2-hydroxytetraeicosanoic acid
    7. SCHEMBL338278
    8. CHEBI:61302
    9. CTK6D9796
    10. LMFA01050080
      1. AKOS027379899
      2. AK390113
      3. DB-052577
      4. FT-0632358
      5. C17873
      6. C-49361
       Haen hakusanalla phrenosic acid lisätietoja.
      http://www.hmdb.ca/metabolites/HMDB0039540
       DL-Cerebronic acid, also known as acide cerebronique or cerebronsaeure, belongs to the class of organic compounds known as very long-chain fatty acids. These are fatty acids with an aliphatic tail that contains at least 22 carbon atoms.
       DL-Cerebronic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. DL-Cerebronic acid has been primarily detected in urine. Within the cell, DL-cerebronic acid is primarily located in the membrane (predicted from logP), cytoplasm and adiposome. DL-Cerebronic acid participates in a number of enzymatic reactions. In particular, DL-cerebronic acid can be biosynthesized from tetracosanoic acid. DL-Cerebronic acid is also a parent compound for other transformation products, including but not limited to, N-2-hydroxylignoceroylsphingosine, 2-hydroxytetracosanoyl-CoA, and N-(2-hydroxylignoceroyl)-D-galactosylsphingosine. Outside of the human body, DL-cerebronic acid can be found in mushrooms. This makes DL-cerebronic acid a potential biomarker for the consumption of this food product.

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