Hepoxiliineja ja trioxiliineja alettu selvittää edelleen 2018

https://www.ncbi.nlm.nih.gov/pubmed/29317615

Nat Commun. 2018 Jan 9;9(1):128. doi: 10.1038/s41467-017-02543-8.

Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes.

An JU¹, Song YS¹, Kim KR¹, Ko YJ², Yoon DY¹, Oh DK³.

Abstract

Hepoxilins (HXs) and trioxilins (TrXs) are involved in physiological processes such as inflammation, insulin secretion and pain perception in human. They are metabolites of polyunsaturated fatty acids (PUFAs), including arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid, formed by 12-lipoxygenase (LOX) and epoxide hydrolase (EH) expressed by mammalian cells.
 Here, we identify ten types of HXs and TrXs, produced by the prokaryote Myxococcus xanthus, of which six types are new, namely, HXB₅, HXD₃, HXE₃, TrXB₅, TrXD₃ and TrXE₃.
 We succeed in the biotransformation of PUFAs into eight types of HXs (>35% conversion) and TrXs (>10% conversion) by expressing M. xanthus 12-LOX or 11-LOX with or without EH in Escherichia coli. We determine 11-hydroxy-eicosatetraenoic acid, HXB₃, HXB₄, HXD₃, TrXB₃ and TrXD₃ as potential peroxisome proliferator-activated receptor-γ partial agonists. These findings may facilitate physiological studies and drug development based on lipid mediators.

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https://www.ncbi.nlm.nih.gov/pubmed/26666460
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https://www.ncbi.nlm.nih.gov/pubmed/26677076 
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5. Angioneogenesis??  Tästä löytyi : psoriasis.
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895645/figure/F2/
6. hepoxilin, psoriasis
 https://www.ncbi.nlm.nih.gov/pubmed/?term=hepoxilin%2C+psoriasis