Tetrakosahexaeenin vaikutuksista

Vaikuttaa siltä että tetrakosahexaeeni (n-3) on tyypillinen DOKOSANOIDI, jonka vaiktukset myötäävät EPA ja DOHA vaikutuksia.
Se vähentää myös histamiinia kuten EPA ja DHA.
Kaikkien omega-3 sarjan happojen ei mahdollisesti ole tarkoitus muuttua juuri DHA-muotoon. DHA on tyypillinen neuronin haluama muoto, mutta onhan aivosoluja kaikenlaisia ja olisi luonnollista, että tätä muotoa on siten myös joissain profiilinsa paikoissa . mitkä ne sitten lienevät. Ei vaikuta suoranaiselta haittahapolta ollenkaan. Haitta on tietysti jos puuttuu mahdollisuus sen muuttumiseen neuronin tarvitsemaan DHA-muotoon.

Voss et al.reported that 24:6n-3 is formed as an intermediate in the metabolic pathway from 20:5n-3 to 22:6n-3 in rat liver.

Even though 24:6n-3 is a PUFA existing in fish and mammalian species, physiological functions of 24:6n-3 have not been studied

As functions to be studied, anti-inflammatory and antiallergic effects of 24:6n-3 are noteworthy because these events are known to be closely related to the unsaturated fatty acid metabolism such as in the arachidonic acid cascade, and 20:5n-3 and 22:6n-3 were reported to suppress inflammatory actions by influencing arachidonic acid metabolism 24:6n-3 could inhibit the antigen-stimulated production of LT-related compounds as well as other n-3 polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3), which are major n-3 PUFA in fish oils;

24:6n-3 was also shown to reduce the histamine content in MC/9 cells at 25 uM (27% reduction from the control), and the effect was diminished with increase of the fatty acid concentration (up to 100 uM).

These two n-3 PUFA, 20:5n-3 and 22:6n-3, also reduced the histamine content (16 and 20% reduction at 25 μM, respectively), whereas arachidonic acid (20:4n-6) increased it (18% increase at 25 μM).