Tietoja OXER1 reseptorista PubMed hakulaiteella tietueesta :
Otan yhden artikkelin sitaattina: Siitä käy ilmi että OXER1 -reseptoriin vastavaikuttaa omega3-linjasta tuleva DHA*, dokosahexaeenihappo eli kalarasvoissa oleva pitkäketjuinen rasvahappo. Merkkaan tähdellä tämän lauseen:
Mol Cell Endocrinol. 2013 May 22;371(1-2):71-8. doi: 10.1016/j.mce.2012.11.003. Epub 2012 Nov 16.
Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells.
Abstract
Hormonal
regulation of steroidogenesis involves arachidonic acid (AA) metabolism
through the 5-lipoxygenase pathway. One of the products,
5-hydroperoxy-eicosatetraenoic acid (5-HpETE), acts as a modulator of
the activity of the steroidogenic acute regulatory (StAR) protein
promoter. Besides, an oxoeicosanoid receptor of the leukotriene receptor
family named OXE-R is a membrane protein with high affinity and
response to 5-HpETE, among other AA derivatives.
- The aim of our work was to elucidate whether this receptor may be involved in steroidogenesis. RT-PCR and western blot analysis demonstrated the presence of the mRNA and protein of the receptor in human H295R adrenocortical cells. The treatment of H295R or MA-10 cells (murine Leydig cell line) with 8Br-cAMP together with docosahexaenoic acid (DHA*, an antagonist of the receptor) partially reduced StAR induction and steroidogenesis. On the contrary, 5-oxo-ETE - the prototypical agonist, with higher affinity and potency on the receptor - increased cAMP-dependent steroid production, StAR mRNA and protein levels. These results lead us to conclude that AA might modulate StAR induction and steroidogenesis, at least in part, through 5-HpETE production and activation of a membrane receptor, such as the OXE-R.
- PMID:
- 23159987
- DOI:
- 10.1016/j.mce.2012.11.003
Inga kommentarer:
Skicka en kommentar