Kardiolipiinisyntaasi

https://previous.genecards.org/cgi-bin/carddisp.pl?gene=CRLS1&keywords=Cardiolipin

Aliases for CRLS1 Gene

• GeneCards Symbol: CRLS1 2 
• Cardiolipin Synthase 1 2 3 5
• CLS1 2 3 4 5
• DJ967N21.6 2 3 5
• C20orf155 3 4 5
• GCD10 2 3 5
• Cardiolipin Synthase (CMP-Forming) 3 4

• CLS 3 4
• Chromosome 20 Open Reading Frame 155 2
• GCD10 Homolog (S. Cerevisiae) 2
• Protein GCD10 Homolog 4
• EC 2.7.8.41 4
• COSPD57 3

External Ids for CRLS1 Gene

• This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016]

GeneCards Summary for CRLS1 Gene

CRLS1 (Cardiolipin Synthase 1) is a Protein Coding gene. Diseases associated with CRLS1 include Combined Oxidative Phosphorylation Deficiency 57 and Charcot-Marie-Tooth Disease, X-Linked Dominant, 6. Among its related pathways are Glycerophospholipid biosynthesis and Glycerophospholipid biosynthetic pathway. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. An important paralog of this gene is HDHD5.

UniProtKB/Swiss-Prot Summary for CRLS1 Gene

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG) (PubMed:16547353, 16678169, 16716149, 35147173). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the funct