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lördag 1 april 2017

Sfingosiinin aineenvaihdunta karttaa

Fig. 1. Pathways for the biosynthesis of sphingosine 1-phosphate in the blood. Sphingomyelin is hydrolyzed by sphingomyelinase to ceramide. Then, ceramide is converted into sphingosine by ceramidase and sphingosine is incorporated into red blood cells or platelets. Sphingosine 1-phosphate is produced by sphingosine kinase from sphingosine in these blood cells. On the other hand, sphingomyelin is also converted to sphingosylphosphorylcholine, which can be catabolized to sphingosine 1-phosphate by autotaxin. In this fi gure, the involvement of vascular cells is not shown. 
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